Dynamic Security-aware Routing for Zone-based data Protection in Multi-Processor System-on-Chips

In this work, we propose a NoC which enforces the encapsulation of sensitive traffic inside the asymmetrical security zones while using minimal and non-minimal paths. The NoC routes guarantee that the sensitive traffic is communicated only through the trusted nodes which belong to the security zone. As the shape of the zones may change during operation, the sensitive traffic must be routed through low-risk paths. We test our proposal and we show that our solution can be an efficient and scalable alternative for enforce the data protection inside the MPSoC

A Fast Evaluation Approach of Data Consistency Protocols within a Compilation Toolchain

International audienceShared memory is a critical issue for large distributed systems. Despite several data consistency protocols have been proposed, the selection of the protocol that best suits to the application requirements and system constraints remains a challenge. The development of multi-consistency systems, where different protocols can be deployed during runtime, appears to be an interesting alternative. In order to explore the design space of the consistency protocols a fast and accurate method should be used. In this work we rely on a compilation toolchain that transparently handles data consistency decisions for a multi-protocol platform. We focus on the analytical evaluation of the consistency configuration that stands within the optimization loop. We propose to use a TLM NoC simulator to get feedback on expected network contentions. We evaluate the approach using five workloads and three different data consistency protocols. As a result, we are able to obtain a fast and accurate evaluation of the different consistency alternatives

Side-Channel Protected MPSoC through Secure Real-Time Networks-on-Chip

The integration of Multi-Processors System-on-Chip (MPSoCs) into the Internet -of -Things (IoT) context brings new opportunities, but also represent risks. Tight real-time constraints and security requirements should be considered simultaneously when designing MPSoCs. Network-on-Chip (NoCs) are specially critical when meeting these two conflicting characteristics. For instance the NoC design has a huge influence in the security of the system. A vital threat to system security are so-called side-channel attacks based on the NoC communication observations. To this end, we propose a NoC security mechanism suitable for hard real-time systems, in which schedulability is a vital design requirement. We present three contributions. First, we show the impact of the NoC routing in the security of the system. Second, we propose a packet route randomisation mechanism to increase NoC resilience against side-channel attacks. Third, using an evolutionary optimisation approach, we effectively apply route randomisation while controlling its impact on hard real-time performance guarantees. Extensive experimental evidence based on analytical and simulation models supports our findings

Fallopia japonica and Impatiens glandulifera are colonized by species-poor root-associated fungal communities but have minor impacts on soil properties in riparian habitats

Fallopia japonica and Impatiens glandulifera are major plant invaders on a global scale that often become dominant in riparian areas. However, little is known about how these species affect interactions in soil-plant systems. The aim of this study was to investigate the impact of both species on abiotic and biotic soil properties, with a special focus on fungi. We investigated eight sites along small streams invaded by F. japonica and I. glandulifera, respectively, and compared each with nearby sites dominated by the native species Urtica dioica. Three different types of samples were collected: bulk soil, rhizosphere soil and roots from invasive and native stands at each site. Bulk soil samples were analysed for soil physicochemical, microbial properties (soil microbial respiration and ergosterol) and soil arthropod abundance (Acari and Collembola). Soil respiration was also evaluated in rhizosphere samples. The fungal community composition of both bulk soil and roots were analysed using a metabarcoding approach. Soil physicochemical properties as well as soil microbial activity, fungal biomass and soil fungal operational unit taxonomic unit (OTU) richness did not differ between invaded and native riparian habitats, indicating only minor belowground impacts of the two invasive plant species. Soil microbial activity, fungal biomass and soil fungal OTU richness were rather related to the soil physicochemical properties. In contrast, Acari abundance decreased by 68% in the presence of F. japonica, while Collembola abundance increased by 11% in I. glandulifera sites. Moreover, root-associated fungal communities differed between the invasive and native plants. In F. japonica roots, fungal OTU richness of all investigated ecological groups (mycorrhiza, endophytes, parasites, saprobes) were lower compared to U. dioica. However, in I. glandulifera roots only the OTU richness of mycorrhiza and saprobic fungi was lower. Overall, our findings show that F. japonica and I. glandulifera can influence the abundance of soil arthropods and are characterized by lower OTU richness of root-associated fungi

QoSS Hierarchical NoC-Based Architecture for MPSoC Dynamic Protection

As electronic systems are pervading our lives, MPSoC (multiprocessor system-on-chip) security is becoming an important requirement. MPSoCs are able to support multiple applications on the same chip. The challenge is to provide MPSoC security that makes possible a trustworthy system that meets the performance and security requirements of all the applications. The network-on-chip (NoC) can be used to efficiently incorporate security. Our work proposes the implementation of QoSS (quality of security service) to overcome present MPSoC vulnerabilities. QoSS is a novel concept for data protection that introduces security as a dimension of QoS. QoSS takes advantage of the NoC wide system visibility and critical role in enabling system operation, exploiting the NoC components to detect and prevent a wide range of attacks. In this paper, we present the implementation of a layered dynamic security NoC architecture that integrates agile and dynamic security firewalls in order to detect attacks based on different security rules. We evaluate the effectiveness of our approach over several MPSoCs scenarios and estimate their impact on the overall performance. We show that our architecture can perform a fast detection of a wide range of attacks and a fast configuration of different security policies for several MPSoC applications

Propuesta de diseño para un puesto de trabajo dentro del CEDI de Newell Brands de Colombia S.A.S. a partir del estudio ergonómico

La aplicación de la ergonomía en los puestos de trabajo dentro de una empresa es fundamental para la mejora de las condiciones de trabajo de los empleados, mejorando así la productividad y salud de estos. Uno de los problemas más recurrentes en los puestos de trabajo donde se emplea esfuerzo físico son los Desórdenes Músculo Esqueléticos (DME), ya que estos se originan cuando el empleado tiene que hacer un sobreesfuerzo durante su trabajo. Aunque los síntomas no se presentan inmediatamente, si son acumulativos, lo que reduce el rendimiento del empleado, afectando a la empresa y a la vez que le puede generar secuelas a largo plazo. Actualmente, la empresa Newell Brands en su centro de distribución (CEDI) tiene la mayoría de sus actividades manuales, por lo que está expuesta a varias lesiones de DME creando microtraumas. Este problema se trató a través de un estudio ergonómico que consistió en realizar un reporte de incomodidad de los operarios del CEDI a partir del cual se concluyó que los puestos de trabajo más afectados se encontraban en el área de maquila y en la de picking, a estos puestos se les realizaron más estudios los cuales consistieron en la evaluación de movimientos repetitivos (con la metodología OCRA), evaluación de posturas (RULA) y mediciones fisiológicas (frecuencia cardiaca y mediciones antropométricas). Por último, se realizó una o varias propuestas de diseño para los problemas encontrados en el estudio ergonómico.The application of ergonomics in the workplace within a company is essential for improving the working conditions of employees, thus improving their productivity and health. One of the most recurrent problems in jobs where physical effort is used is Musculoskeletal Disorders (MSDs) since these are the consequences when the employee has to overexert during his work. Although the symptoms do not appear immediately, they are cumulative, which reduces the employee's performance, affecting the company and at the same time, it can generate long-term consequences. Currently, the company Newell Brands in its distribution center (DC) performs most of its activities manually, so the workers are exposed to several MSDs injuries that create microtraumas. This problem was addressed through an ergonomic study that consisted of making a report of self-discomfort to the operators of the DC, from which it was concluded that the most affected positions were maquila and picking. Several studies were carried out in these positions which consisted in the evaluation of repetitive movements (with the OCRA methodology) and evaluation of postures (RULA methodology), and physiological measurements (heart rate and anthropometric measurements). Finally, several proposals were designed for the problems found in the ergonomic study.Ingeniero (a) IndustrialPregrad

Effectiveness of the Epley's maneuver performed in primary care to treat posterior canal benign paroxysmal positional vertigo: study protocol for a randomized controlled trial

Background: Vertigo is a common medical condition with a broad spectrum of diagnoses which requires an integrated approach to patients through a structured clinical interview and physical examination. The main cause of vertigo in primary care is benign paroxysmal positional vertigo (BPPV), which should be confirmed by a positive D-H positional test and treated with repositioning maneuvers. The objective of this study is to evaluate the effectiveness of Epley's maneuver performed by general practitioners (GPs) in the treatment of BPPV. Methods/Design: This study is a randomized clinical trial conducted in the primary care setting. The study's scope will include two urban primary care centers which provide care for approximately 49,400 patients. All patients attending these two primary care centers, who are newly diagnosed with benign paroxysmal positional vertigo, will be invited to participate in the study and will be randomly assigned either to the treatment group (Epley's maneuver) or to the control group (a sham maneuver). Both groups will receive betahistine. Outcome variables will be: response to the D-H test, patients' report on presence or absence of vertigo during the previous week (dichotomous variable: yes/no), intensity of vertigo symptoms on a Likert-type scale in the previous week, total score on the Dizziness Handicap Inventory (DHI) and quantity of betahistine taken. We will use descriptive statistics of all variables collected. Groups will be compared using the intent-to-treat approach and either parametric or nonparametric tests, depending on the nature and distribution of the variables. Chi-square test or Fisher's exact test will be conducted to compare categorical measures and Student's t-test or Mann-Whitney U-test will be used for intergroup comparison variables. Discussion: Positive results from our study will highlight that treatment of benign paroxysmal positional vertigo can be performed by trained general practitioners (GPs) and, therefore, its widespread practice may contribute to improve the quality of life of BPPV patients

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN